: The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

Scaramuzzo, Gaetano
Primo
;
Mari, Matilde;Montanaro, Federica;David, Antonio;Caramori, Gaetano
;
Volta, Carlo Alberto;Spadaro, Savino
Ultimo
2023

Abstract

: The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
2023
Scaramuzzo, Gaetano; Nucera, Francesco; Asmundo, Alessio; Messina, Roberto; Mari, Matilde; Montanaro, Federica; Johansen, Matt D; Monaco, Francesco; Fadda, Guido; Tuccari, Giovanni; Hansbro, Nicole G; Hansbro, Philip M; Hansel, Trevor T; Adcock, Ian M; David, Antonio; Kirkham, Paul; Caramori, Gaetano; Volta, Carlo Alberto; Spadaro, Savino
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2506211
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