The synthesis and biological activity on human neutrophils of for-Met-(γ-lactam)-Leu-Phe-OMe [fM(γl)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.
Synthesis and biological activity of a conformationally constrained chemotactic γ-lactam formyl tetrapeptide
Cavicchioni G.
;Reali E.;Spisani S.
1996
Abstract
The synthesis and biological activity on human neutrophils of for-Met-(γ-lactam)-Leu-Phe-OMe [fM(γl)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
