Background: There are limited data regarding COVID-19 vaccination during pregnancy. Objectives: To evaluate the effects of COVID-19 vaccination received during preg- nancy on SARS-CoV-2 infection, COVID-19-related hospitalisation, COVID-19- related intensive care unit (ICU) admission and maternal–fetal complications. Search strategy: MEDLINE, CINHAL, Embase, Scopus and CENTRAL databases, as well as ClinicalTrials.gov, reference lists, related articles and grey literature sources. Selection criteria: Randomised controlled trials, non-randomised studies of inter- ventions, pregnant women, COVID-19 vaccination during pregnancy. Data collection and analysis: Study selection, risk-of-bias assessment, data extrac- tion and assessment of the certainty of evidence using the GRADE method were performed independently by two authors. Meta-analyses were performed using Cochrane RevMan 5.4. PROSPERO registration number: CRD42022308849. Main results: We included 14 observational studies (362 353 women). The adminis- tration of a COVID-19 vaccine during pregnancy resulted in a statistically significant reduction in SARS-CoV-2 infection (OR 0.46, 95% CI 0.28–0.76) and COVID-19- related hospitalisation (OR 0.41, 95% CI 0.33–0.51). The effect appeared to be greater in fully vaccinated women, for both infection (OR 0.31, 95% CI 0.16–0.59) and hos- pitalisation (OR 0.15, 95% CI 0.10–0.21). However, the certainty of evidence was very low. The difference in COVID-19-related ICU admission between vaccinated and unvaccinated individuals did not reach statistical significance (OR 0.58, 95% CI 0.13–2.58). Finally, there were no statistically significant differences in any of the maternal–fetal complications considered in the included studies. Conclusions: COVID-19 vaccination administered during pregnancy seems to re- duce SARS-CoV-2 infection and COVID-19-related hospitalisation, with no signifi- cant effects on maternal–fetal complications.

Effectiveness and safety of COVID-19 vaccine in pregnant women: A systematic review with meta-analysis

Mara Tormen
;
Cristina Taliento;Stefano Salvioli;Irene Piccolotti;Gennaro Scutiero;Rosaria Cappadona;Pantaleo Greco.
2023

Abstract

Background: There are limited data regarding COVID-19 vaccination during pregnancy. Objectives: To evaluate the effects of COVID-19 vaccination received during preg- nancy on SARS-CoV-2 infection, COVID-19-related hospitalisation, COVID-19- related intensive care unit (ICU) admission and maternal–fetal complications. Search strategy: MEDLINE, CINHAL, Embase, Scopus and CENTRAL databases, as well as ClinicalTrials.gov, reference lists, related articles and grey literature sources. Selection criteria: Randomised controlled trials, non-randomised studies of inter- ventions, pregnant women, COVID-19 vaccination during pregnancy. Data collection and analysis: Study selection, risk-of-bias assessment, data extrac- tion and assessment of the certainty of evidence using the GRADE method were performed independently by two authors. Meta-analyses were performed using Cochrane RevMan 5.4. PROSPERO registration number: CRD42022308849. Main results: We included 14 observational studies (362 353 women). The adminis- tration of a COVID-19 vaccine during pregnancy resulted in a statistically significant reduction in SARS-CoV-2 infection (OR 0.46, 95% CI 0.28–0.76) and COVID-19- related hospitalisation (OR 0.41, 95% CI 0.33–0.51). The effect appeared to be greater in fully vaccinated women, for both infection (OR 0.31, 95% CI 0.16–0.59) and hos- pitalisation (OR 0.15, 95% CI 0.10–0.21). However, the certainty of evidence was very low. The difference in COVID-19-related ICU admission between vaccinated and unvaccinated individuals did not reach statistical significance (OR 0.58, 95% CI 0.13–2.58). Finally, there were no statistically significant differences in any of the maternal–fetal complications considered in the included studies. Conclusions: COVID-19 vaccination administered during pregnancy seems to re- duce SARS-CoV-2 infection and COVID-19-related hospitalisation, with no signifi- cant effects on maternal–fetal complications.
2023
Tormen, Mara; Taliento, Cristina; Salvioli, Stefano; Piccolotti, Irene; Scutiero, Gennaro; Cappadona, Rosaria; Greco, Pantaleo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2501354
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