Abscopal effect has been mentioned for a long time, but only recently a deeper knowledge about underlying mechanisms supporting the interaction between immune system and radiation therapy became available. Furthermore, the introduction of immune-checkpoint inhibitors makes appealing the idea of combining them with radiotherapy (RT) to elicit abscopal effect and ideally revert an intrinsic or acquired resistance. Herein, we present the case of a non-small-cell lung cancer patient undergoing, during second line nivolumab, palliative RT on thoracic wall lesion, achieving a complete response in the metastatic adrenal site. This case report suggests that the abscopal effect exists in clinical practice of lung cancer care likely due to a synergism between immune-checkpoint and RT, even when administered with a palliative intent.

Abscopal effect and resistance reversion in nivolumab-treated non-small-cell lung cancer undergoing palliative radiotherapy: a case report

Francesco Fiorica
;
Lorenzo Belluomini
;
Jacopo Giuliani;Antonio Frassoldati;Carlotta Giorgi
2021

Abstract

Abscopal effect has been mentioned for a long time, but only recently a deeper knowledge about underlying mechanisms supporting the interaction between immune system and radiation therapy became available. Furthermore, the introduction of immune-checkpoint inhibitors makes appealing the idea of combining them with radiotherapy (RT) to elicit abscopal effect and ideally revert an intrinsic or acquired resistance. Herein, we present the case of a non-small-cell lung cancer patient undergoing, during second line nivolumab, palliative RT on thoracic wall lesion, achieving a complete response in the metastatic adrenal site. This case report suggests that the abscopal effect exists in clinical practice of lung cancer care likely due to a synergism between immune-checkpoint and RT, even when administered with a palliative intent.
Fiorica, Francesco; Belluomini, Lorenzo; Giuliani, Jacopo; Urbini, Benedetta; Milella, Michele; Frassoldati, Antonio; Pilotto, Sara; Giorgi, Carlotta
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2497794
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