Up to now, no role has been associated with VRAC channels in T cells. In a recent paper published in Nature Immunology, LRRC8C has been described as an essential component of VRAC in T cells. These data raise the intriguing possibility that the LRRC8C-STING-p53 signaling axis may represent a new inhibitory pathway in T cells that controls their function and adaptive immunity.

The LRRC8C-STING-p53 axis in T cells: A Ca2+ affair

Missiroli, Sonia
Primo
;
Giorgi, Carlotta
Secondo
;
Pinton, Paolo
Ultimo
2022

Abstract

Up to now, no role has been associated with VRAC channels in T cells. In a recent paper published in Nature Immunology, LRRC8C has been described as an essential component of VRAC in T cells. These data raise the intriguing possibility that the LRRC8C-STING-p53 signaling axis may represent a new inhibitory pathway in T cells that controls their function and adaptive immunity.
2022
Missiroli, Sonia; Giorgi, Carlotta; Pinton, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2497645
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