A rapid and efficient synthesis of 1-benzyl-2-difluoromethyl-piperazine is herein described. The new pathway has the advantage of avoiding orthogonal protection at the two piperazine nitrogen atoms; therefore it is suitable for access to several 1-benzyl 2-substituted piperazines starting from the simple commercially available N,N'-dibenzylethylendiamine. Copyright © 2011 Taylor & Francis Group, LLC.
Rapid access to 1-benzyl 2-substituted piperazines: Application to the synthesis of 1-benzyl-2-difluoromethyl-piperazine
Napolitano C.;Manfredini S.
2011
Abstract
A rapid and efficient synthesis of 1-benzyl-2-difluoromethyl-piperazine is herein described. The new pathway has the advantage of avoiding orthogonal protection at the two piperazine nitrogen atoms; therefore it is suitable for access to several 1-benzyl 2-substituted piperazines starting from the simple commercially available N,N'-dibenzylethylendiamine. Copyright © 2011 Taylor & Francis Group, LLC.File in questo prodotto:
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