Purpose COVID-19 has worse clinical outcomes in males compared with females and testosterone may determine gender differences. Hypogonadism and supernumerary X chromosome may have a role in the SARS-CoV-2 infection in Klinefelter syndrome (KS). Aim of the study was evaluating COVID-19 frequency and severity in KS. Methods Participants were invited to complete a retrospective self-administered questionnaire containing multiple choice and open-ended answers. Results COVID-19 was detected in 10% of the evaluated KS subjects; none was hospitalized. 44.4% of COVID-19 patients had one cohabitant-infected versus 3% of non-infected (p < 0.01). Testosterone levels in infected patients were lower compared to those of non-infected subjects (3.1 ± 1.2 ng/ml vs. 5.2 ± 2 ng/ml, p < 0.05). Conclusions The frequency of SARS-CoV-2 infection among KS subjects was 10%. All infected patients showed mild symptoms. The presence of one affected cohabitant significantly associated with SARS-CoV-2 infection. An association between SARS-CoV-2 and hypogonadism was confirmed.

Investigation of COVID‑19 infection in subjects with Klinefelter syndrome

L. Aliberti;I. Gagliardi;S. Lupo;M. Verrienti;M. Bondanelli;M. C. Zatelli
Penultimo
;
M. R. Ambrosio
2022

Abstract

Purpose COVID-19 has worse clinical outcomes in males compared with females and testosterone may determine gender differences. Hypogonadism and supernumerary X chromosome may have a role in the SARS-CoV-2 infection in Klinefelter syndrome (KS). Aim of the study was evaluating COVID-19 frequency and severity in KS. Methods Participants were invited to complete a retrospective self-administered questionnaire containing multiple choice and open-ended answers. Results COVID-19 was detected in 10% of the evaluated KS subjects; none was hospitalized. 44.4% of COVID-19 patients had one cohabitant-infected versus 3% of non-infected (p < 0.01). Testosterone levels in infected patients were lower compared to those of non-infected subjects (3.1 ± 1.2 ng/ml vs. 5.2 ± 2 ng/ml, p < 0.05). Conclusions The frequency of SARS-CoV-2 infection among KS subjects was 10%. All infected patients showed mild symptoms. The presence of one affected cohabitant significantly associated with SARS-CoV-2 infection. An association between SARS-CoV-2 and hypogonadism was confirmed.
Aliberti, L.; Gagliardi, I.; Lupo, S.; Verrienti, M.; Bondanelli, M.; Zatelli, M. C.; Ambrosio, M. R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2488901
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