Background The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. MethodsFour hundred and ninety three adult patients from 27 Italian centers (recruited in 2011-2014) were analyzed. ResultsMean age was 53.8years. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40years); the mean age for asthma symptoms onset was 30.2years and for asthma diagnosis 34.4years. 97.1% used ICS (dose 2000 BDP), 93.6% LABA in association with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean FEV1% pred of 75.1%, median values of 300/mm(3) of blood eosinophil count, 323kU/L of serum total IgE, and 24ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity (OR, 95% CI 2.46, 1.11-5.41), psychic disorders (2.87, 0.89-9.30borderline), nasal polyps (1.86, 0.88-3.89borderline), partial/poor asthma treatment adherence (2.54, 0.97-6.67borderline), and anti-IgE use in a protective way (0.26, 0.12-0.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations. ConclusionsAn international effort in the implementation of SUA patients' registries could help to better understand the clinical features and to manage severe asthma, representing a non-negligible socioeconomic burden for health services.

RItA: The Italian severe/uncontrolled asthma registry

Murgia, N.;
2018

Abstract

Background The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. MethodsFour hundred and ninety three adult patients from 27 Italian centers (recruited in 2011-2014) were analyzed. ResultsMean age was 53.8years. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40years); the mean age for asthma symptoms onset was 30.2years and for asthma diagnosis 34.4years. 97.1% used ICS (dose 2000 BDP), 93.6% LABA in association with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean FEV1% pred of 75.1%, median values of 300/mm(3) of blood eosinophil count, 323kU/L of serum total IgE, and 24ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity (OR, 95% CI 2.46, 1.11-5.41), psychic disorders (2.87, 0.89-9.30borderline), nasal polyps (1.86, 0.88-3.89borderline), partial/poor asthma treatment adherence (2.54, 0.97-6.67borderline), and anti-IgE use in a protective way (0.26, 0.12-0.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations. ConclusionsAn international effort in the implementation of SUA patients' registries could help to better understand the clinical features and to manage severe asthma, representing a non-negligible socioeconomic burden for health services.
2018
Maio, S.; Baldacci, S.; Bresciani, M.; Simoni, M.; Latorre, M.; Murgia, N.; Spinozzi, F.; Braschi, M.; Antonicelli, L.; Brunetto, B.; Iacovacci, P.; R...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2488771
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