Skin may be affected by many disorders that can be treated by topical applications of drugs on the action site. With the advent of nanotechnologies new efficient delivery systems have been developed. Particularly, lipid-based nanosystems such as liposomes, ethosomes, transferosomes, solid lipid nanoparticles, nanostructured lipid carriers, cubosomes and monoolein aqueous dispersions, have been proposed for cutaneous application, reaching in some cases the market or clinical trials. This review aims to provide an overview of the different lipid-based nanosystems, focusing on their use for topical application. Particularly, the description of biocompatible nanosystems able to dissolve lipophilic compounds and to control the release of carried drug possibly reducing side effects is outlined. Notably, the rationale to topically administer antioxidant molecules by lipid nanocarriers is described. Indeed, the structural similarity between the nanosystem lipid matrix and the skin lipids allows the achievement of a transdermal effect. Surely more research is required to better understand the mechanism of interaction between li-pid-based nanosystems and skin. However, this attempt to summarize and highlight the possibilities offered by lipid-based nanosystems could help the scientific community to take advantage of the benefits derived from this kind of nanosystems.

Lipid-based nanosystems as a tool to overcome skin barrier

M. Sguizzato
Primo
;
E. Esposito
Secondo
;
R. Cortesi
Ultimo
2021

Abstract

Skin may be affected by many disorders that can be treated by topical applications of drugs on the action site. With the advent of nanotechnologies new efficient delivery systems have been developed. Particularly, lipid-based nanosystems such as liposomes, ethosomes, transferosomes, solid lipid nanoparticles, nanostructured lipid carriers, cubosomes and monoolein aqueous dispersions, have been proposed for cutaneous application, reaching in some cases the market or clinical trials. This review aims to provide an overview of the different lipid-based nanosystems, focusing on their use for topical application. Particularly, the description of biocompatible nanosystems able to dissolve lipophilic compounds and to control the release of carried drug possibly reducing side effects is outlined. Notably, the rationale to topically administer antioxidant molecules by lipid nanocarriers is described. Indeed, the structural similarity between the nanosystem lipid matrix and the skin lipids allows the achievement of a transdermal effect. Surely more research is required to better understand the mechanism of interaction between li-pid-based nanosystems and skin. However, this attempt to summarize and highlight the possibilities offered by lipid-based nanosystems could help the scientific community to take advantage of the benefits derived from this kind of nanosystems.
2021
Sguizzato, M.; Esposito, E.; Cortesi, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2462724
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