Mammalian cells express a large number of structurally distinct ion channels on the cell surface and also in the membranes of intracellular organelles. They can selectively permeate ion species (thus named Ca2+, Na+, K+ or Cl− channels according to their selectivity) or a group of positively or negatively charged ions (non-selective cation or anion channels) (Hille, 2001). Their activity is regulated by diverse physical, biochemical or biological stimuli of the microenvironments and, as such, they initial or control important signaling mechanisms involved in a wide range of cellular processes which are critical for cancer development and progression including cell differentiation, proliferation, migration and apoptosis. It comes no surprise that an alteration in ion channel expression and/or activity is causatively associated with manifestation of cancer hallmarks (Hanahan and Weinberg, 2011), leading to the introduction of oncochannels (Huber, 2013). This Research Topic collects 16 review and original research articles, which provide idea-provoking insights or new research regarding the role of ion channels in cancer and the concept or efforts of targeting them to treat cancer.

Editorial: Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics

Adinolfi E.
Secondo
;
Roger S.
Ultimo
2021

Abstract

Mammalian cells express a large number of structurally distinct ion channels on the cell surface and also in the membranes of intracellular organelles. They can selectively permeate ion species (thus named Ca2+, Na+, K+ or Cl− channels according to their selectivity) or a group of positively or negatively charged ions (non-selective cation or anion channels) (Hille, 2001). Their activity is regulated by diverse physical, biochemical or biological stimuli of the microenvironments and, as such, they initial or control important signaling mechanisms involved in a wide range of cellular processes which are critical for cancer development and progression including cell differentiation, proliferation, migration and apoptosis. It comes no surprise that an alteration in ion channel expression and/or activity is causatively associated with manifestation of cancer hallmarks (Hanahan and Weinberg, 2011), leading to the introduction of oncochannels (Huber, 2013). This Research Topic collects 16 review and original research articles, which provide idea-provoking insights or new research regarding the role of ion channels in cancer and the concept or efforts of targeting them to treat cancer.
2021
Jiang, L. -H.; Adinolfi, E.; Roger, S.
File in questo prodotto:
File Dimensione Formato  
fphar-12-711593.pdf

accesso aperto

Descrizione: Full text editoriale
Tipologia: Full text (versione editoriale)
Licenza: Creative commons
Dimensione 534.02 kB
Formato Adobe PDF
534.02 kB Adobe PDF Visualizza/Apri

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2459528
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact