The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase. Copyright © 2005 by AAN Enterprises, Inc.

rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

Koch G
Primo
;
2005

Abstract

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase. Copyright © 2005 by AAN Enterprises, Inc.
2005
Koch, G; Brusa, L; Caltagirone, C; Peppe, A; Oliveri, M; Stanzione, P; Centonze, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2452704
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