Mechanisms of synaptic plasticity like long term depression (LTD) are altered in experimentalmodels of Alzheimer’s disease (AD). LTD-like plasticity mechanisms has not been yet fully investigated inAD patients. Dopamine modulation of LTD-like plasticity is impaired when tested in AD patients. These findings provide evidence of possible dysfunction of dopaminergic transmission in ADpatients.

Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients

Koch G
Primo
;
2011

Abstract

Mechanisms of synaptic plasticity like long term depression (LTD) are altered in experimentalmodels of Alzheimer’s disease (AD). LTD-like plasticity mechanisms has not been yet fully investigated inAD patients. Dopamine modulation of LTD-like plasticity is impaired when tested in AD patients. These findings provide evidence of possible dysfunction of dopaminergic transmission in ADpatients.
2011
Koch, G; Esposito, Z; Codecà, C; Mori, F; Kusayanagi, H; Monteleone, F; Di Lorenzo, F; Bernardi, G; Martorana, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2447624
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