Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been largely studied in the last years, especially in view of their potential use for treating diseases, damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteo-blasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, in-cluding microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approxi-mately 22 nucleotides able to regulate cell proliferation, differentiation and apoptosis by binding the 3′ untranslated region (3′-UTR) of target mRNAs, which can be subsequently degraded or trans-lationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-β)/bone mor-phogenic protein (BMP) and the Wingless/Int-1(Wnt)/β-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.

MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells

Chiara Mazziotta
Co-primo
Writing – Original Draft Preparation
;
Carmen Lanzillotti
Co-primo
Writing – Original Draft Preparation
;
Maria Rosa Iaquinta
Co-primo
Writing – Original Draft Preparation
;
Elena Torreggiani
Writing – Review & Editing
;
John Charles Rotondo
Writing – Review & Editing
;
Lucia Oton Gonzalez
Visualization
;
Elisa Mazzoni
Visualization
;
Francesca Frontini
Methodology
;
Ilaria Bononi
Software
;
Monica De Mattei
Conceptualization
;
Mauro Tognon
Penultimo
Conceptualization
;
Fernanda Martini
Ultimo
Conceptualization
2021

Abstract

Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been largely studied in the last years, especially in view of their potential use for treating diseases, damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteo-blasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, in-cluding microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approxi-mately 22 nucleotides able to regulate cell proliferation, differentiation and apoptosis by binding the 3′ untranslated region (3′-UTR) of target mRNAs, which can be subsequently degraded or trans-lationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-β)/bone mor-phogenic protein (BMP) and the Wingless/Int-1(Wnt)/β-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.
2021
Mazziotta, Chiara; Lanzillotti, Carmen; Iaquinta, Maria Rosa; Taraballi, Francesca; Torreggiani, Elena; Rotondo, John Charles; OTON GONZALEZ, Lucia; Mazzoni, Elisa; Frontini, Francesca; Bononi, Ilaria; DE MATTEI, Monica; Tognon, Mauro; Martini, Fernanda
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2442225
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