It has been long recognized that dual-energy imaging could help to enhance the detectability of lesions in diagnostic radiology, by removing the contrast of surrounding tissues. Furthermore, X-ray attenuation is material specific and information about the object constituents can be extracted for tissue characterisation, i.e., to assess whether lesions represent a malignant or benign process. However, a true separation between the low and high energy components is not possible with conventional sources because of their broad X-ray spectrum, and the artifacts produced in the subtracted image can be only partially removed. Finally, dose issues have also prevented so far the application of dual-energy techniques within the clinical context. Very recently, a new intense and monochromatic X-ray source was proposed to fill the gap between a synchrotron radiation facility and the standard X-ray tube. Indeed, inverse Compton scattering (ICS) sources, which are based on the interaction of a powerful laser beam and a bright beam of relativistic electrons, are among the most promising innovative sources of monochromatic X and gamma radiation. In this contribution, we review the main features that allow an ICS source to meet the requirements of a medical imaging application. Specific examples of K-edge subtraction are then provided, to show the potential of ICS in clinical applications that require intravenous injection of a contrast medium.

Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

Paternò, Gianfranco
Primo
;
Cardarelli, Paolo
Secondo
;
Gambaccini, Mauro
Penultimo
;
Taibi, Angelo
Ultimo
2020

Abstract

It has been long recognized that dual-energy imaging could help to enhance the detectability of lesions in diagnostic radiology, by removing the contrast of surrounding tissues. Furthermore, X-ray attenuation is material specific and information about the object constituents can be extracted for tissue characterisation, i.e., to assess whether lesions represent a malignant or benign process. However, a true separation between the low and high energy components is not possible with conventional sources because of their broad X-ray spectrum, and the artifacts produced in the subtracted image can be only partially removed. Finally, dose issues have also prevented so far the application of dual-energy techniques within the clinical context. Very recently, a new intense and monochromatic X-ray source was proposed to fill the gap between a synchrotron radiation facility and the standard X-ray tube. Indeed, inverse Compton scattering (ICS) sources, which are based on the interaction of a powerful laser beam and a bright beam of relativistic electrons, are among the most promising innovative sources of monochromatic X and gamma radiation. In this contribution, we review the main features that allow an ICS source to meet the requirements of a medical imaging application. Specific examples of K-edge subtraction are then provided, to show the potential of ICS in clinical applications that require intravenous injection of a contrast medium.
2020
Paternò, Gianfranco; Cardarelli, Paolo; Gambaccini, Mauro; Taibi, Angelo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2433164
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