Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease whose exact etiopathogenesis remains unknown. Immunological alterations and chronic inflammation seem to be crucial pathomechanisms. Promoting fibroblast growth and activity, as well as collagen synthesis, is another key event [1]. However, the chief mediators associated with immunological and tissue changes and the link between immune dysreactivity and altered collagen metabolism are poorly known.
Tissue cytokine/chemokine profile in vulvar lichen sclerosus: An observational study on keratinocyte and fibroblast cultures
Monica CorazzaPrimo
;Lucia Oton-GonzalezSecondo
;Valeria Scuderi;John Charles Rotondo;Carmen Lanzillotti;Giulia Di Mauro;Mauro Tognon;Fernanda Martini;Alessandro Borghi
Ultimo
2020
Abstract
Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease whose exact etiopathogenesis remains unknown. Immunological alterations and chronic inflammation seem to be crucial pathomechanisms. Promoting fibroblast growth and activity, as well as collagen synthesis, is another key event [1]. However, the chief mediators associated with immunological and tissue changes and the link between immune dysreactivity and altered collagen metabolism are poorly known.File in questo prodotto:
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Corazza et al., 2020.pdf
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