Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Pasin M
Membro del Collaboration Group
;
Fabbian F
Membro del Collaboration Group
;
Manfredini R
Membro del Collaboration Group
;
2017

Abstract

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.
Cohen, At; Gitt, Ak; Bauersachs, R; Fronk, Em; Laeis, P; Mismetti, P; Monreal, M; Willich, Sn; Bramlage, P; Agnelli, G; Brodmann, M; Rief, P; Eischer, L; Stoshikj, S; Hirschl, M; Weinmann, S; Peter Marschang, P; Abbadie, F; Achkar, A; Addala, A; Reynaldo, P; Adnet, F; Alexandra, Jf; Aquilanti, S; Belhassane, A; Benaroya, B; Berremili, T; Grenot, Mc; Birr, V; Holtea, D; Bonnin, C; Bosler, F; Bresin Durand, Mg; Brisot, D; Brousse, C; De La Fuente, T; Cayman, C; Cazaubon, M; Champion, O; Chanut, M; Chevalet, P; Connault, J; Durant, C; Constans, J; Cordeanu, M; Couturaud, F; Lacut, K; De Dedker, L; Piloquet, Fx; Decoulx, E; Derrien, B; Diamand, Jm; Diard, A; Douadi, Y; Dupas, S; Modeliar Remond, Ss; Sevestre, Ma; Edhery, S; Falvo, N; Farcas Taralunga, C; Ferrari, E; Gaillard, C; Garrigues, D; Gillet, Jl; Giordana, P; Grange, C; Vital-Durand, D; Grare, F; Hadj Henni, A; Heuser, S; Schmidt, J; Hidden-Henic, V; Hottin, D; Imbert, B; Pernod, G; Jakob, D; Jacquinandi, V; Jurus, C; Lacoste, A; Laroche, Jp; Martin, M; Mazollier, C; Mersel, T; Miserey, G; Nedey, C; Nou, M; Quere, I; Ouvry, P; Peuch, B; Pichot, O; Poulain, V; Ray, P; Rifai, A; Roy, Pm; Saby, Jc; Simon, F; Simonot-Lalandec, E; Stephan, D; Tissot, A; Vodoungnon, H; Adamczyk, A; Schnabl, S; Al Ahmad, W; Weber, H; Axthelm, C; Axthelm, P; Bauersachs, R; Bergmann, K; Beschorner, U; Knittel, M; Binias, Kh; Pasligh, M; Boral, M; Girke, F; Bratsch, H; Brauer, G; Burghard, S; Demann, C; Rennebaum, C; Emter, E; Demmig, A; Eberlein, U; Enger, F; Eschenburg, J; Eschenburg, Ju; Forkmann, L; Frank, J; Freischmidt, H; Gassauer, M; Fritsche, I; Kubicek–hofmann, C; Goebels, Mc; Guggenbichler, S; Härtel, D; Hartmann, K; Heilberger, P; Heinsius, A; Held, M; Schnupp, S; Herman, G; Herold, J; Hertrich, F; Hommel, H; Hütte, G; Kalka, C; Jungandreas, K; Ramthor, M; Karcher, J; Werner, N; Karl-Wollweber, S; Keilhau, Da; Kittel, K; Knolinski, T; Köhler, C; Werth, S; Kopplin, U; Körner, I; Wittig, K; Dres, P; Kröger, K; Moysidis, T; Kroschel, U; Leschke, M; zur Nieden, T; Lübbert, G; Lutz, A; Wucherpfennig, P; Marencke, Gh; Mortensen, K; Reppel, M; Nelles, H; Nestler, K; Neumeister, A; Schlosser, A; Oettler, W; Ott, I; Otto, A; Pertermann, A; Pfister, R; Pindur, P; Pourhassan, S; Predel, D; Pudollek, T; Reimer, D; Richter, R; Eberhad Rieker, E; Rothenbücher, G; Rothhagen, B; Rudolff, S; Stücker, M; Schäfer, A; Sonnenschein, K; Schafnitzl, W; Schellong, S; Voigts, B; Schiller, M; Schmeink, T; Schmeink, P; Schneider, H; Schön, N; Schulze, M; Sechtem, U; Sedl, S; Werno, Hs; Stachowitz, J; Thieme, M; Tiefenbacher, C; Tsantilas, D; Vieth, P; vom Dahl, J; Grün-Himmelmann, K; von Bilderling, P; von Maltik, T; Weinrich, K; Weyer, M; Wirtz, P; Wittig, I; Zierock, P; Ageno, W; Caprioli, C; Rancan, E; Agnelli, G; Guercini, F; Mommi, V; Amitrano, M; Cannavacciuolo, F; Amore, M; D'Antoni, S; Angelini, E; La Forgia, S; Antignani, Pl; Calandra, G; Arone, A; Perticone, F; Sciacqua, A; Asaro, G; Bellisi, M; Attanzio, Mt; Pinto, A; Attinasi, V; Cillari, E; Sorvillo, S; Balbarini, A; Santini, C; Violo, C; Banfi, E; Lodigiani, C; Barcellona, D; Delpin, S; Marongiu, S; Barillari, G; Pasca, S; Bartolini, C; Verdecchia, P; Bartone, M; Mancuso, G; Bellanuova, I; Felis, S; Bellizzi, A; Masotti, L; Bianchi, M; Carugati, A; Bianchini, G; Guarnera, G; Boari, B; Gallerani, M; Pasin, M; Bortoluzzi, C; Parisi, R; Brucoli, C; Palasciano, G; Camporese, G; Tonello, C; Canafoglia, L; Rupoli, S; Cancellieri, E; Paoletti, O; Testa, S; Carlizza, A; Carnovali, M; Sada, S; Samaden, A; Casarsa, C; Mearelli, F; Pivetti, G; Catalini, R; Zingaretti, O; Cavazza, S; Cosmi, B; Cenci, C; Prisco, D; Silvestri, E; Ceresa, F; Patanè, F; Ciampa, A; Siniscalchi, V; Ciarambino, T; De Bartolomeo, G; Clemente, M; Conti, F; Paiella, L; D’Avino, M; D'Alessandro, A; Placentino, M; Sollazzo, V; D'Angelo, A; Viganò, S; De Campora, P; Sangiuolo, R; De Franciscis, S; Serra, R; De Gaudenzi, E; De Santis, F; Piccinni, Gc; De Tommaso, I; Di Francesco, L; Vincentelli, Gm; Di Maggio, R; Saccullo, G; Siragusa, S; Di Micco, P; Fontanella, A; Di Michele, D; Di Minno, G; Tufano, A; Di Nisio, M; Porreca, E; Donadio, F; Imberti, D; Enea, I; Fabbian, F; Manfredini, R; Pala, P; Falanga, A; Milesi, V; Fiore, V; Signorelli, Ss; Franco, E; Giudice, G; Frausini, G; Rovinelli, M; Fuorlo, M; Landolfi, R; Morretti, T; Gamberini, S; Salmi, R; Ghirarduzzi, A; Ghizzi, G; Pepe, C; Gianniello, F; Martinelli, I; Iosub, Di; Piovella, F; Iozzi, E; Talerico, A; La Regina, M; Orlandini, F; Marconi, L; Palla, A; Marcucci, R; Poli, D; Margheriti, R; Sala, G; Marra, A; Marrocco, F; Montagna, Es; Silvestris, F; Vallarelli, S; Mos, L; Rossetto, V; Mugno, F; Di Salvo, M; Nitti, C; Pennacchioni, M; Salvi, A; Olivieri, O; Tosi, F; Zorzi, F; Onesta, M; Pagliara, V; Villalta, S; Paolucci, G; Severino, S; Pierri, F; Russo, V; Pizzini, Am; Quintavalla, R; Rubino, P; Ria, L; Schenone, A; Strafino, C; Tropeano, P; Vetrano, V; Zanatta, N; Adarraga Cansino, Md; Gutierrez, Ja; de las Revillas, Fa; Amado Fernández, C; Calvo Mijares, N; Blanco-Molina, Ma; Garcia, Ma; Joya Seijo, D; Aranda Blazquez, R; López-Sáez, Jb; Arellano Rodrigo, E; Villalta Blanch, J; Armengou Arxe, A; García-Bragado Dalmau, F; Ballaz Quincoces, A; García Loizaga, A; Beato Pérez, Jl; Bedate Díaz, P; Quezada Loaiza, A; Castellote, Mc; Cañas Alcántara, I; Lluís Padierna, M; Carrasco Expósito, M; Millón Caño, Ja; Carrasco Mas, A; Cereto Castro, F; Castrodeza Sanz, R; Ortiz de Saracho, J; Cisneros de la Fuente, E; de Ancos Aracil, C; Ruiz, J; de Daborenea González, Md; Fernández Iglesias, A; de la Fuente Aguado, J; González, Lg; del Carmen Fernández-Capitán, M; Lorenzo Hernández, A; del Toro Cervera, J; Pérez Rus, G; Delgado Bregel, Jl; Díez Fernández, F; Santalla Valle, Ea; Elias Hernández, T; Jara Palomares, L; Ferri Bataler, R; Nieto Rodríguez, Ja; García García, Jm; Villanueva Montes, Ma; González Porras, Jr; Guil García, M; San Román Terán, Cm; Hernando López, E; Roncero Lázaro, A; Jaras, Mj; Jiménez Castro, D; Jiménez-Rodríguez Madridejos, R; Pedrajas Navas, Jm; Lecumberri, R; Martínez, N; López Castellanos, Gt; Manzano Espinosa, L; López Jiménez, L; Madridano Cobo, O; Mainez Saiz, C; Romero Pizarro, Y; Marchena Yglesias, Pj; Martín del Pozo, M; Melibovsky, L; Altarriba, Es; Monreal Bosch, M; Monte Secades, R; Mora Luján, Jm; Riera Mestre, A; Moral Moral, P; Todolí Parra, Ja; Moreno Flores, A; Sánchez Muñoz-Torrero, Jf; Muñoz Rodríguez, Fj; Núñez Fernández, Mj; Oncala Sibajas, E; Vaquero de Sedas, M; Parra Caballero, P; Pons Martín del Campo, I; Portillo Sánchez, J; Rivera Gallego, A; Villaverde Álvarez, I; Rodríguez Beltrán, Em; Sánchez Fuentes, D; Roldán Schilling, V; Sánchez Álvarez, J; López, Gt; Suriñach Caralt, Jm; Tirado Miranda, R; Usandizaga de Antonio, E; Banyai, M; Frank, U; Jörg, Gr; Jeanneret, C; Staub, D; Ackroyd, A; Agarwal, G; Mearns, B; Alikhan, R; Allameddine, A; Al-Refaie, F; Arden, C; Austin, A; Bakhai, A; Barton, T; Ewad, H; Body, R; Thachil, J; Chacko, J; Chandra, D; Charters, F; Church, A; Mcgrane, F; Clements, J; Clifford, P; Cox, D; Crouch, M; Crowther, M; Davies, E; Davies, M; Dimitri, S; Drebes, A; Franklin, S; George, J; Irvine, N; Gerofke, H; Gibbs, C; Goh, T; Gupta, S; Holmes, J; Jackson-Voyzey, E; Jones, N; Kallat, A; Kerr, P; Kesteven, P; Lench, T; Lester, W; Lowe, G; Lewis, M; Mccormack, T; Mccoye, A; Moriarty, A; Morris, W; Narayanan, M; Oo, N; Reed, M; Rose, P; Saja, K; Sivakumaran, M; Sohal, M; Solomons, G; Sultanzadeh, Sj; Venton, T; Wakeling, J; Walby, C; Waldron, M; Watt, S; Willcock, W; Zafar, A.
File in questo prodotto:
File Dimensione Formato  
2017.the management vte registry.pdf

accesso aperto

Tipologia: Full text (versione editoriale)
Licenza: Creative commons
Dimensione 456.42 kB
Formato Adobe PDF
456.42 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2421362
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 56
social impact