Cytomegalovirus (CMV) infection is a major complica- tion in immunocompromised patients, including those with autoimmune diseases. Here, we describe the first case of granulomatosis with polyangiitis treated with steroids and cyclophosphamide, complicated by a multi- drug-resistant (MDR) CMV infection in presence of weak antiviral cellular immunity. Since reports regarding CMVinfection in rheumatological patients are rarely described and no guidelines on its management exist, the described case contributes to identify potential strategies to pre- dict the risk of CMV disease and developing of MDR-CMV in these patients, through virological and immunological surveillance.

Multidrug-Resistant Cytomegalovirus Infection in a Patient With Granulomatosis With Polyangiitis During Immunosuppressive Treatment

Martina Maritati
Writing – Review & Editing
;
Renato La Corte
Membro del Collaboration Group
;
Carlo Contini
Penultimo
Writing – Review & Editing
;
2020

Abstract

Cytomegalovirus (CMV) infection is a major complica- tion in immunocompromised patients, including those with autoimmune diseases. Here, we describe the first case of granulomatosis with polyangiitis treated with steroids and cyclophosphamide, complicated by a multi- drug-resistant (MDR) CMV infection in presence of weak antiviral cellular immunity. Since reports regarding CMVinfection in rheumatological patients are rarely described and no guidelines on its management exist, the described case contributes to identify potential strategies to pre- dict the risk of CMV disease and developing of MDR-CMV in these patients, through virological and immunological surveillance.
2020
Piccirilli, Giulia; Chiereghin, Angela; Maritati, Martina; Turello, Gabriele; Felici, Silvia; LA CORTE, Renato; Gabrielli, Liliana; Contini, Carlo; La...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2419322
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