Paroxysmal nocturnal hemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene in hematopoietic stem cells and is characterized by the triad of intravascular hemolysis, severe acquired thrombophilia, and multiple cytopenias. The occurrence of cytopenias is thought to be an expression of bone marrow failure (BMF), and due to this consideration, a number of authors have recently investigated the presence of PNH clones in aplastic anemias (AA) and related disorders. Practical guidelines for the high sensitivity detection and monitoring of PNH clones by flow cytometry have been recently published in Cytometry B.
Issue highlights - May 2014
Lanza F.
Primo
Writing – Review & Editing
2014
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene in hematopoietic stem cells and is characterized by the triad of intravascular hemolysis, severe acquired thrombophilia, and multiple cytopenias. The occurrence of cytopenias is thought to be an expression of bone marrow failure (BMF), and due to this consideration, a number of authors have recently investigated the presence of PNH clones in aplastic anemias (AA) and related disorders. Practical guidelines for the high sensitivity detection and monitoring of PNH clones by flow cytometry have been recently published in Cytometry B.| File | Dimensione | Formato | |
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