Uridine diphosphoglucuronosyl transferase 1A1 (UGT1A1) *28 polymorphism reduces UGT1A1 enzymatic activity and is possibly associated with irinotecan(IRI)-induced neutropenia and diarrhea. The aim of this single-centre analysis is to assess if IRI dose-reduction according to UGT1A1 status can avoid severe toxicities.
Can irinotecan dose reduction according to ugt1a1 genotype avoid severe toxicities?
F. Daniel
Primo
Writing – Original Draft Preparation
;L. BelluominiSecondo
;F. Lancia;L. Martella;I. Toma;A. Moretti;I. Carandina;M. FabbriPenultimo
Formal Analysis
;A. FrassoldatiUltimo
Writing – Review & Editing
2016
Abstract
Uridine diphosphoglucuronosyl transferase 1A1 (UGT1A1) *28 polymorphism reduces UGT1A1 enzymatic activity and is possibly associated with irinotecan(IRI)-induced neutropenia and diarrhea. The aim of this single-centre analysis is to assess if IRI dose-reduction according to UGT1A1 status can avoid severe toxicities.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
