Despite convincing experimental evidence, epidemiological studies on the effects of serum uric acid (SUA) on bone health are still conflicting since factors influencing SUA bioavailability have not been adequately considered. To shed some light on this issue, we investigated the impact of adiposity and menopause status on the relationship between SUA and bone health. We examined SUA in relation to bone mineral density (BMD) at different skeletal sites and with markers of bone metabolism in 124 pre-menopausal and 234 post-menopausal women and assessed whether adiposity, evaluated by anthropometry and dual x-ray absorptiometry (DXA), might have a discriminant role. After conservative adjustment (covariates: age, hormones treatment, smoking and time since menopause), SUA showed a significant and positive association with total hip BMD (β = 0.220, p < 0.01) among postmenopausal women, maintained also after adjustment for legs adiposity. Notably, stratification for waist circumference quartiles revealed that the correlation between SUA and total hip BMD was significant (r = 0.444, p = 0.001) in the highest quartile (91–100 cm). Our results suggest that SUA might be beneficial for bone health in postmenopausal women being characterized by a more android fat distribution, ascribing to SUA a discriminant role during menopause transition, potentially relevant also for men.

Changes in adipose tissue distribution and association between uric acid and bone health during menopause transition

Bonaccorsi, Gloria
Primo
Conceptualization
;
Trentini, Alessandro
Secondo
Investigation
;
Greco, Pantaleo
Membro del Collaboration Group
;
Tisato, Veronica
Investigation
;
Gemmati, Donato
Supervision
;
Bianchi, Nicoletta
Membro del Collaboration Group
;
Giganti, Melchiore
Membro del Collaboration Group
;
Guglielmi, Giuseppe
Penultimo
Membro del Collaboration Group
;
Cervellati, Carlo
Ultimo
Writing – Original Draft Preparation
2019

Abstract

Despite convincing experimental evidence, epidemiological studies on the effects of serum uric acid (SUA) on bone health are still conflicting since factors influencing SUA bioavailability have not been adequately considered. To shed some light on this issue, we investigated the impact of adiposity and menopause status on the relationship between SUA and bone health. We examined SUA in relation to bone mineral density (BMD) at different skeletal sites and with markers of bone metabolism in 124 pre-menopausal and 234 post-menopausal women and assessed whether adiposity, evaluated by anthropometry and dual x-ray absorptiometry (DXA), might have a discriminant role. After conservative adjustment (covariates: age, hormones treatment, smoking and time since menopause), SUA showed a significant and positive association with total hip BMD (β = 0.220, p < 0.01) among postmenopausal women, maintained also after adjustment for legs adiposity. Notably, stratification for waist circumference quartiles revealed that the correlation between SUA and total hip BMD was significant (r = 0.444, p = 0.001) in the highest quartile (91–100 cm). Our results suggest that SUA might be beneficial for bone health in postmenopausal women being characterized by a more android fat distribution, ascribing to SUA a discriminant role during menopause transition, potentially relevant also for men.
2019
Bonaccorsi, Gloria; Trentini, Alessandro; Greco, Pantaleo; Tisato, Veronica; Gemmati, Donato; Bianchi, Nicoletta; Giganti, Melchiore; Rossini, Maurizio; Guglielmi, Giuseppe; Cervellati, Carlo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2412873
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