Pathogens represent a tremendous burden on the reproductive fitness of humans, tailoring variations in endometrial immune cells. As such, the immune phenotypes of endometrial immune cells can have a profound effect on how an infectious pathogen might reduce the reproductive fitness of individuals in a population. HHV-6 is a betaherpesvirus that exists as two closely related variants, HHV-6A and HHV-6B. Recently, HHV-6 infection of the female genital tract has been implicated in pregnancy-related diseases. In particular, the presence of HHV-6 infection of the endometrial epithelial cells seems to be associated with female idiopathic infertility, causing a specific modification of gene expression in both endometrium and endometrial natural killer cells.

Infection and Endometrial Gene Expression: HHV-6 and Infertility

Roberta Rizzo
2019

Abstract

Pathogens represent a tremendous burden on the reproductive fitness of humans, tailoring variations in endometrial immune cells. As such, the immune phenotypes of endometrial immune cells can have a profound effect on how an infectious pathogen might reduce the reproductive fitness of individuals in a population. HHV-6 is a betaherpesvirus that exists as two closely related variants, HHV-6A and HHV-6B. Recently, HHV-6 infection of the female genital tract has been implicated in pregnancy-related diseases. In particular, the presence of HHV-6 infection of the endometrial epithelial cells seems to be associated with female idiopathic infertility, causing a specific modification of gene expression in both endometrium and endometrial natural killer cells.
2019
978-3-030-28583-8
978-3-030-28584-5
Cytokine, IL-15, Endometrial biopsy, Endometrial gene expression, Endometriosis, Endometrium, Female infertility, Gynecological malignancy, HHV-6, Immune profiling, MicroRNA, Progesterone, Recurrent implantation failure, Recurrent pregnancy loss, Uterine fibroid
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2411011
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