The Selfish-Brain hypothesis as possible cause of arterial hypertension: a modeling study

We use a global closed loop multiscale mathematical model of the human circulation to study a novel vascular hypothesis about the onset of essential hypertension. We extend the Muller-Toro model accounting for a precise cerebellum and brainstem vascular network, an autoregulation mechanism of brain hemodynamics, a detailed cerebrospinal fluid dynamics. We present preliminary computational results about the impact of some vascular cerebral anatomical malformations on cerebral perfusion and blood flow before the onset of arterial hypertension.