Long-term follow-up of children and young adults with autoimmune hepatitis treated with cyclosporine

Background: Cyclosporine (CSA)is an alternative treatment for autoimmune hepatitis (AIH), however, its unknown long-term safety and efficacy have limited its use. Aims: Examine the long-term outcome of children and young adults with AIH treated with CSA for at least 4 years. Methods: Twenty patients were included in this retrospective study: 15 with classical AIH and 5 with autoimmune hepatitis/autoimmune sclerosing cholangitis overlap syndrome (ASC). CSA was administered as first (12 patients)or second-line (8 patients)treatment, alone or in combination with azathioprine or mycophenolate mofetil and/or prednisone. Results: CSA determined initial clinical and biochemical remission in all patients. At the end of follow-up (median 8.6; range 4–20.4 years), all patients are alive with their native liver; 15 in complete remission (75%), 2 with incomplete response to treatment and 3 listed for liver transplant. Side effects were mild and transitory after dose tapering or, in 1 case, after CSA withdrawal. Hypertrichosis and moderate gingival hyperplasia were the most frequent. Two patients presented mild transient glomerular filtration rate (GFR)reduction. Median GFR at the beginning and end of treatment was not statistically different for all patients. Conclusions: CSA was effective and safe in the long-term treatment of our cohort of patients with AIH, tailoring the treatment remains key-points during CSA administration.