In chronic obstructive pulmonary disease (COPD), exacerbation history is the strongest predictor of future exacerbation risk. Large cohort studies have shown that patients with one exacerbation in the previous year have an approximately two-fold increased future exacerbation risk compared to patients with no exacerbations, the risk increasing to five-fold in those with two or more exacerbations. Most clinical trials of pharmacological treatments designed to prevent exacerbations have therefore used the inclusion criterion of at least one exacerbation in the previous year, with a minority requiring at least two exacerbations.

Extrafine triple therapy in patients with symptomatic COPD and history of one moderate exacerbation

Fabbri, Leonardo M
Secondo
;
Papi, Alberto
Ultimo
2019

Abstract

In chronic obstructive pulmonary disease (COPD), exacerbation history is the strongest predictor of future exacerbation risk. Large cohort studies have shown that patients with one exacerbation in the previous year have an approximately two-fold increased future exacerbation risk compared to patients with no exacerbations, the risk increasing to five-fold in those with two or more exacerbations. Most clinical trials of pharmacological treatments designed to prevent exacerbations have therefore used the inclusion criterion of at least one exacerbation in the previous year, with a minority requiring at least two exacerbations.
2019
Singh, Dave; Fabbri, Leonardo M; Corradi, Massimo; Georges, George; Guasconi, Alessandro; Vezzoli, Stefano; Petruzzelli, Stefano; Papi, Alberto
File in questo prodotto:
File Dimensione Formato  
1900235.full.pdf

accesso aperto

Tipologia: Full text (versione editoriale)
Licenza: Creative commons
Dimensione 443.46 kB
Formato Adobe PDF
443.46 kB Adobe PDF Visualizza/Apri

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2404388
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 10
social impact