Ambulatory blood pressure monitoring (ABPM) is now considered by current guidelines to be a reliable method of measurement for the diagnosis and assessment of hypertension. The aim of this study was to relate the short-term outcomes, comorbidity and ABPM findings determined from evaluating an everyday clinical cohort of hypertensive patients. A prospective study was carried out that included hypertensive patients who had undergone 24-h ABPM from January 2016 to November 2017. The following parameters were recorded in the database: age, sex, current antihypertensive treatment and documented history of comorbidities. New episodes of myocardial infarction and stroke requiring hospitalization during follow-up obtained from electronic medical records were considered to be major adverse cardiovascular events (MACE) and were our main outcome measures. To estimate the risk of MACE, a Cox multivariate analysis was carried out. We analysed 1521 ABPM values and recorded 33 MACE during a follow-up of 518 +/- 120 days; 15 patients suffered a myocardial infarction and 18 patients had a stroke. The mean age of the patients was 59.9 +/- 14.2 years, and 49.4% were men. Night-time systolic blood pressure (BP), mean BP and pulse pressure were higher in patients who suffered a MACE. Age [hazard ratio (HR): 1.031, 95% confidence interval (CI): 1.002-1.060; P=0.036], night-time BP (HR: 1.018, 95% CI: 1.001-1.037; P=0.044) and diabetes mellitus (HR: 2.393, 95% CI: 1.053-5.436; P=0.037) were associated independently with MACE. We conclude that night-time BP is an important parameter to evaluate in aged patients with diabetes as a predictor of MACE. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.

Early prognostic value of nocturnal blood pressure: a single-centre experience

Fabbian F
Primo
Writing – Original Draft Preparation
;
Tonelli L;De Giorgi A;Cappadona R
Methodology
;
Pasin M
Penultimo
Formal Analysis
;
Manfredini R.
Ultimo
Writing – Review & Editing
2019

Abstract

Ambulatory blood pressure monitoring (ABPM) is now considered by current guidelines to be a reliable method of measurement for the diagnosis and assessment of hypertension. The aim of this study was to relate the short-term outcomes, comorbidity and ABPM findings determined from evaluating an everyday clinical cohort of hypertensive patients. A prospective study was carried out that included hypertensive patients who had undergone 24-h ABPM from January 2016 to November 2017. The following parameters were recorded in the database: age, sex, current antihypertensive treatment and documented history of comorbidities. New episodes of myocardial infarction and stroke requiring hospitalization during follow-up obtained from electronic medical records were considered to be major adverse cardiovascular events (MACE) and were our main outcome measures. To estimate the risk of MACE, a Cox multivariate analysis was carried out. We analysed 1521 ABPM values and recorded 33 MACE during a follow-up of 518 +/- 120 days; 15 patients suffered a myocardial infarction and 18 patients had a stroke. The mean age of the patients was 59.9 +/- 14.2 years, and 49.4% were men. Night-time systolic blood pressure (BP), mean BP and pulse pressure were higher in patients who suffered a MACE. Age [hazard ratio (HR): 1.031, 95% confidence interval (CI): 1.002-1.060; P=0.036], night-time BP (HR: 1.018, 95% CI: 1.001-1.037; P=0.044) and diabetes mellitus (HR: 2.393, 95% CI: 1.053-5.436; P=0.037) were associated independently with MACE. We conclude that night-time BP is an important parameter to evaluate in aged patients with diabetes as a predictor of MACE. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.
2019
Fabbian, F; Tonelli, L; De Giorgi, A; Cappadona, R; Pasin, M; Manfredini, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2404316
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