Mitochondrial Ca2+ transport is a highly conserved phenomenon that is linked to a diverse set of cellular processes, including programmed cell death and inflammation. Given the lack of cell-permeant uniporter inhibitors and the previously unknown molecular identity of the uniporter, the functional studies to date have been largely correlative. The innovative aspect of the current project consists in carrying out a set of targeted genetic and biochemical studies that will enable a detailed molecular understanding of mitochondrial Ca2+ uptake and the mechanisms that govern its regulation. Moreover it offers initial clues to the relevance of these pathways in human stomach and colorectal cancers and highlights the importance of mitochondrial Ca2+ regulation in tumor progression.

Analysis of the modulation of the MCU complex expression and activity in stomach and colorectal cancers

Alessandro rimessi
Co-primo
2018

Abstract

Mitochondrial Ca2+ transport is a highly conserved phenomenon that is linked to a diverse set of cellular processes, including programmed cell death and inflammation. Given the lack of cell-permeant uniporter inhibitors and the previously unknown molecular identity of the uniporter, the functional studies to date have been largely correlative. The innovative aspect of the current project consists in carrying out a set of targeted genetic and biochemical studies that will enable a detailed molecular understanding of mitochondrial Ca2+ uptake and the mechanisms that govern its regulation. Moreover it offers initial clues to the relevance of these pathways in human stomach and colorectal cancers and highlights the importance of mitochondrial Ca2+ regulation in tumor progression.
In corso di stampa
Nazionale
Coordinatore
MINISTERO DELLA SALUTE
Rimessi, Alessandro
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2395924
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact