The present invention relates to ureido derivatives of naphthalenesulfonic acids having anti-heparanase activity. In particular, it relates to derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds. It also relates to the use of such compounds in the treatment of diseases where an inhibition of heparanase is desired, in particular cancer, and to pharmaceutical compositions comprising the same
Derivatives of the Disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as Heparanase inhibitors for the treatment of cancer
Simoni Daniele;SEMERARO, Floriana;Rondanin Riccardo
2017
Abstract
The present invention relates to ureido derivatives of naphthalenesulfonic acids having anti-heparanase activity. In particular, it relates to derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds. It also relates to the use of such compounds in the treatment of diseases where an inhibition of heparanase is desired, in particular cancer, and to pharmaceutical compositions comprising the sameFile in questo prodotto:
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