Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.

In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics

Rigolin, Gian Matteo
Primo
;
Saccenti, Elena
Secondo
;
Guardalben, Emanuele;Cavallari, Maurizio;Formigaro, Luca;Zagatti, Barbara;Bassi, Cristian;Lupini, Laura;QUAGLIA, Francesca Maria;URSO, ANTONIO;Bardi, Maria Antonella;VOLTA, Eleonora;Tammiso, Elisa;MELANDRI, AURORA;Cavazzini, Francesco;Negrini, Massimo;Cuneo, Antonio
Ultimo
2018

Abstract

Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.
2018
Rigolin, Gian Matteo; Saccenti, Elena; Guardalben, Emanuele; Cavallari, Maurizio; Formigaro, Luca; Zagatti, Barbara; Visentin, Andrea; Mauro, Francesca R.; Lista, Enrico; Bassi, Cristian; Lupini, Laura; Quaglia, Francesca Maria; Urso, Antonio; Bardi, Maria Antonella; Bonaldi, Laura; Volta, Eleonora; Tammiso, Elisa; Ilari, Caterina; Cafforio, Luciana; Melandri, Aurora; Cavazzini, Francesco; Negrini, Massimo; Semenzato, Gianpietro; Trentin, Livio; Foà, Robin; Cuneo, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2391960
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