(WO200592374) Provided is a replication-deficient HSV encoding a heterologous antigen, and a vaccine comprising the HSV.The vaccine may be directed to viruses, intracellular bacteria or tumours.Also provided is an anticancer vaccine comprising replication-deficient HSV encoding an angiogenesis inhibitor, a cytokine and a suicide gene.A challenge model for screening candidate antigens is also provided, as is an UL13 mutant HSV vector.Further provided are HSV vectors for expression of Hex A and NTFs, and methods comprising said HSV.
Recombinant herpes simplex virus and uses therefor
Caputo, Antonella;Marconi, Peggy Carla Raffaella
2004
Abstract
(WO200592374) Provided is a replication-deficient HSV encoding a heterologous antigen, and a vaccine comprising the HSV.The vaccine may be directed to viruses, intracellular bacteria or tumours.Also provided is an anticancer vaccine comprising replication-deficient HSV encoding an angiogenesis inhibitor, a cytokine and a suicide gene.A challenge model for screening candidate antigens is also provided, as is an UL13 mutant HSV vector.Further provided are HSV vectors for expression of Hex A and NTFs, and methods comprising said HSV.File in questo prodotto:
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