We previously reported that cynomolgus monkeys vaccinated with the human immunodeficiency virus (HIV)-1 Tat protein controlled infection after challenge with the simian human immunodeficiency virus (SHIV) 89.6Pcy243for up to 2 y of follow-up. To evaluate the breadth of the protective immunity elicited by the Tat protein, the vaccines along with the naïve monkeys were intravenously rechallenged with a fivefold higher dose (50 MID50) of the same SHIV-89.6Pcy243. The vaccinated monkeys exhibited a statistically significant and long-lasting reduction of viral replication compared to control monkeys. This effect was associated with a strong anamnestic response to Tat, while responses to Gag and Env were nearly undetectable. Taken together, these data provide further evidence for the usefulness of Tat-based vaccines. © Copyright 2009, Mary Ann Liebert, Inc.

Containment of infection in Tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6Pcy243

Caputo, Antonella;
2009

Abstract

We previously reported that cynomolgus monkeys vaccinated with the human immunodeficiency virus (HIV)-1 Tat protein controlled infection after challenge with the simian human immunodeficiency virus (SHIV) 89.6Pcy243for up to 2 y of follow-up. To evaluate the breadth of the protective immunity elicited by the Tat protein, the vaccines along with the naïve monkeys were intravenously rechallenged with a fivefold higher dose (50 MID50) of the same SHIV-89.6Pcy243. The vaccinated monkeys exhibited a statistically significant and long-lasting reduction of viral replication compared to control monkeys. This effect was associated with a strong anamnestic response to Tat, while responses to Gag and Env were nearly undetectable. Taken together, these data provide further evidence for the usefulness of Tat-based vaccines. © Copyright 2009, Mary Ann Liebert, Inc.
2009
Borsetti, Alessandra; Baroncelli, Silvia; Maggiorella, Maria Teresa; Moretti, Sonia; Fanales-Belasio, Emanuele; Sernicola, Leonardo; Tripiciano, Antonella; Macchia, Iole; Michelini, Zuleika; Belli, Roberto; Farcomeni, Stefania; Pavone-Cossut, Maria Rosaria; Negri, Donatella; Caputo, Antonella; Bellino, Stefania; Butto, Stefano; Titti, Fausto; Cafaro, Aurelio; Ensoli, Barbara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2391433
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