NOVEL ANTITUMOR AGENTS STRUCTURALLY RELATED TO AMINOBISPHOSPHONATES AND STILBENES

Cancer is one of the principal causes of death in the world and its therapy research leads a strong, but nowadays without great results, interest by scientific community. The treatment given for cancer is highly variable and dependent on a number of factors including the type, location and amount of disease and the health status of the patient (surgery, radiation, chemotherapy, hormonal treatment, antibodies, immunotherapy) but the discover of compounds able to kill selectively the affected cells is the main goal for medicinal chemists. With the aim to decrease their toxicity often the different types of treatment are used in combination, either simultaneously or sequentially. In this thesis, the design, synthesis and biological evaluation of two different kinds of anticancer compounds are described. The synthesis of novel aminobisphosphonates compounds leads to the development of new molecules which induce the immune system, enhancing its antitumor effect. This project is involved in immunotherapy field, a promising and no toxic anticancer therapy approach. Moreover, the synthesis of new natural stilbenes related compounds, involved in the cytotoxic chemotherapy field, lead us to develop a set of high activity molecules, which are promising for further pre-clinical and clinical studies.