Phytochemical analysis, antiproliferative against k562 humam chronic myelogenus leukemia, antiviral and hypoglycaemic activities of cedrus species and medicinal plants native from Libanon

There are four kinds of Cedar, three of them naturally present in the Mediterranean Sea region: Cedrus libani, in Lebanon, Syria and Turky, Cedrus atlantica in Algeria and Morocco, Cedrus brevifolia in Cyprus Island While Cedrus deodara in Himalaya Mountains . The wood essential oils of C. libani, C .atalantica and C. deodara inhibited the proliferation of k 562 cell line with IC50 Value of 23.38, 59.37 and 37.09 µg.ml-1 respectively. Meanwhile Cedrus libani wood oils showed a percentage of erythroide differentiation of 15% at the concentration of 5µg.ml-1another side Cedrus deodara wood oil was found a percentage of erythroide differentiation of 20% at the concentration 25µg.ml-1 and Cedrus atlantica wood oils indicated a percentage of erythroide differentiation of 12% at concentration 10µg.ml-1 The essential oils obtained from different officinal plants of Lebanon, belonging to the Magnoliophyta division, have been tested for their antiproliferative activity on humanerythroleukemic K562 cells. Satureja montana showed the most interesting biological activity in inhibiting the cell growth and inducing erythroid differentiation of K562 cells The essential oil of Satureja montana was therefore analyzed using a GC/MS (gas chromatography/mass spectrometry) system in order to identify the major constituents and compare them with analysis performed on Satureja hortensis. The major constituent of Satureja hortensis being carvacrol (50.61%) and that of Satureja montana being α-terpineol (12.66%). Satureja Montana essential oil displayed different natural derivatives characterized by higher activity than those present in Satureja hortensis. The common active principles are α-pinene, γ-terpinene, 4-terpineol, α-terpineol, τ-cadinene, τ-cadinol and caryophyllene. Both caryophyllene and α-terpineol showed important antiproliferative effects on K562 cells.