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EnglishDespite the fact that majority of studies done using different compounds with antioxidant properties showing pivotal effect on oxidative phosphorylation or glycolytic ATP production, it is still difficult to discuss efficient therapeutic solutions for patients affected by mitochondrial diseases or mitochondrial dysfunction-associated disorders. Since most of the mitochondrial disorders are manifested in tissues or organs that demand high-energy, many experimental studies have described that the pivotal effect of the tested compounds comes from the use of the skin fibroblasts from patients. In this chapter, we have gathered information about these studies and describe the effect of such treatment on mitochondrial function and the attenuation of oxidative stress in patients’ fibroblasts.
| Titolo: | Recovering Mitochondrial Function in Patients’ Fibroblasts | |
| Autori: | DANESE, Alberto (Secondo) PINTON, Paolo (Penultimo) | |
| Data di pubblicazione: | 2018 | |
| Handle: | http://hdl.handle.net/11392/2386185 | |
| ISBN: | 978-3-319-73343-2 978-3-319-73344-9 | |
| Appare nelle tipologie: | 02.1 Contributo in volume (Capitolo, articolo) |
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