By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.
Data di pubblicazione: | 2017 | |
Titolo: | Cannabis through the looking glass: Chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography | |
Autori: | Mazzoccanti, Giulia; Ismail, Omar H.; D’Acquarica, Ilaria; Villani, Claudio; Manzo, C.; Wilcox, M.; Cavazzini, Alberto; Gasparrini, Francesco | |
Rivista: | CHEMICAL COMMUNICATIONS | |
Keywords: | Chiral chromatography, enantioseparations, analytical chemistry, phytocannabinoids, supercritical fluid chromatography | |
Abstract in inglese: | By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity. | |
Digital Object Identifier (DOI): | 10.1039/c7cc06999e | |
Handle: | http://hdl.handle.net/11392/2384314 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |
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