Cannabis through the looking glass: Chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.

Data di pubblicazione: 2017
Titolo: Cannabis through the looking glass: Chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography
Autori: Mazzoccanti, Giulia; Ismail, Omar H.; D’Acquarica, Ilaria; Villani, Claudio; Manzo, C.; Wilcox, M.; Cavazzini, Alberto; Gasparrini, Francesco
Rivista: CHEMICAL COMMUNICATIONS
Keywords: Chiral chromatography, enantioseparations, analytical chemistry, phytocannabinoids, supercritical fluid chromatography
Abstract in inglese: By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.
Digital Object Identifier (DOI): 10.1039/c7cc06999e
Handle: http://hdl.handle.net/11392/2384314
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