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EnglishHIV infection is characterized by several immune dysfunctions, such as chronic activation of the immune system, premature ageing and loss of CD4 T cell, in particular within the naïve compartment. The Tat protein of HIV is released extracellularly and enters neighboring cells affecting their functionality, for instance impacting on CD8 T cell programs and activity. As the presence and/or induction of anti-Tat immune responses is associated with reduced T cell dysfunctions and CD4 T cell loss, we investigated whether Tat impacts human resting or activated CD4 T cells.
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| Titolo: | The HIV-1 Tat protein affects human CD4+ T cell programming and activation, and favors the differentiation of naïve CD4+ T cells |
| Autori: | |
| Data di pubblicazione: | 2018 |
| Rivista: | |
| Abstract: | HIV infection is characterized by several immune dysfunctions, such as chronic activation of the immune system, premature ageing and loss of CD4 T cell, in particular within the naïve compartment. The Tat protein of HIV is released extracellularly and enters neighboring cells affecting their functionality, for instance impacting on CD8 T cell programs and activity. As the presence and/or induction of anti-Tat immune responses is associated with reduced T cell dysfunctions and CD4 T cell loss, we investigated whether Tat impacts human resting or activated CD4 T cells. |
| Handle: | http://hdl.handle.net/11392/2384282 |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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