Aim: We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion. Methodology: Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers. Results: Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration. Conclusion: The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.

Influences of the vehicle in the spreading and release of betamethasone

Molesini, Sonia
Primo
Investigation
;
URTO, Federica
Secondo
Investigation
;
Bettoli, Vincenzo
Conceptualization
;
Valacchi, Giuseppe
Methodology
;
Pecorelli, Alessandra
Investigation
;
Manfredini, Stefano
Penultimo
Supervision
;
Vertuani, Silvia
Ultimo
Writing – Review & Editing
2018

Abstract

Aim: We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion. Methodology: Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers. Results: Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration. Conclusion: The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.
Molesini, Sonia; Urto, Federica; Cvetkovska, Alexandra D.; Bettoli, Vincenzo; Valacchi, Giuseppe; Pecorelli, Alessandra; Manfredini, Stefano; Vertuani, Silvia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2384031
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