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EnglishBackground We have previously demonstrated that peak oxygen uptake (VO2peak) estimated by a moderate one-km treadmill-walking test (1k-TWT) predicts mortality in men with cardiovascular disease and preserved left ventricular ejection fraction (LVEF). Methods and Results We now studied 209 chronic heart failure outpatients aged 35-83 years classified as NYHA class I (LVEF 40±5%), who were referred to an exercise-based secondary prevention programme. VO2peak was determined in all subjects by a previously described 1k-WT. Based on the VO2peak values obtained, participants were subdivided into tertiles. LVEF was not different among the three groups. During a median 9.4 year follow-up, 51 all-causes deaths occurred: 23 in the lowest VO2peak tertile, 11 in the intermediate, and 3 in the highest tertile. Mortality risk increased across decreasing tertiles of VO2peak (P<0.0001). Compared to the lowest tertile, the full-adjusted mortality risk decreased for the second, and third tertile, with Hazard ratios of 0.64 (95% CI: 0.33-1.20, P=0.18), and 0.26 (95% CI: 0.08-0.80, P=0.02), respectively (P for trend <0.0001). Each 1 mL/kg/min increase in VO2peak was associated with a 7% lower risk of death (P=0.04). Conclusions VO2peak estimated by a moderate and self-paced one-km treadmill walk predicts mortality in NYHA class I CHF patients with mid-range left ventricular dysfunction.
| Data di pubblicazione: | 2017 | |
| Titolo: | A moderate 1-km treadmill walk predicts mortality in men with mid-range left ventricular dysfunction | |
| Autori: | Mandini, S; Grazzi, G; Mazzoni, G; Myers, J; Pasanisi, G; Sassone, B; Conconi, F; Chiaranda, G | |
| Rivista: | EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | |
| Keywords: | Chronic heart failure, Exercise capacity, Submaximal exercise testing, Mortality | |
| Abstract in inglese: | Background We have previously demonstrated that peak oxygen uptake (VO2peak) estimated by a moderate one-km treadmill-walking test (1k-TWT) predicts mortality in men with cardiovascular disease and preserved left ventricular ejection fraction (LVEF). Methods and Results We now studied 209 chronic heart failure outpatients aged 35-83 years classified as NYHA class I (LVEF 40±5%), who were referred to an exercise-based secondary prevention programme. VO2peak was determined in all subjects by a previously described 1k-WT. Based on the VO2peak values obtained, participants were subdivided into tertiles. LVEF was not different among the three groups. During a median 9.4 year follow-up, 51 all-causes deaths occurred: 23 in the lowest VO2peak tertile, 11 in the intermediate, and 3 in the highest tertile. Mortality risk increased across decreasing tertiles of VO2peak (P<0.0001). Compared to the lowest tertile, the full-adjusted mortality risk decreased for the second, and third tertile, with Hazard ratios of 0.64 (95% CI: 0.33-1.20, P=0.18), and 0.26 (95% CI: 0.08-0.80, P=0.02), respectively (P for trend <0.0001). Each 1 mL/kg/min increase in VO2peak was associated with a 7% lower risk of death (P=0.04). Conclusions VO2peak estimated by a moderate and self-paced one-km treadmill walk predicts mortality in NYHA class I CHF patients with mid-range left ventricular dysfunction. | |
| Digital Object Identifier (DOI): | 10.1177/2047487317722434 | |
| Handle: | http://hdl.handle.net/11392/2383889 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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