Quantitative analysis of 90Y Bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry

Aim: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) 90Y-Bremsstrahlung images and to validate the S-voxel method. Methods: An anthropomorphic torso phantom with radioactive inserts (90Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with 90Y-DOTATATE. Results: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was <10%, <5%, and <10%, respectively. The absorbed-dose values calculated by OLINDA were in agreement with the mean dose values obtained by the S-voxel method (difference, <10%). Conclusions: The results confirm that, with the hybrid SPECT-CT system, quantitative analysis of SPECT 90Y-Bremsstrahlung images and the generation of three-dmensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy. © Mary Ann Liebert, Inc. 2009.

Data di pubblicazione: 2009
Titolo: Quantitative analysis of 90Y Bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry
Autori: Fabbri, Cinzia; Sarti, Graziella; Cremonesi, Marta; Ferrari, Mahila; Dia, Amalia Di; Agostini, Monica; Botta, Francesca; Paganelli, Giovanni
Rivista: CANCER BIOTHERAPY & RADIOPHARMACEUTICALS
Parole Chiave: 90Y-radionuclide therapy; Bremsstrahlung image quantification; Dose-volume histogram (DVH); SPECT-CT; Voxel dosimetry; Oncology; Radiology, Nuclear Medicine and Imaging; Pharmacology; Cancer Research
Abstract in inglese: Aim: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) 90Y-Bremsstrahlung images and to validate the S-voxel method. Methods: An anthropomorphic torso phantom with radioactive inserts (90Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with 90Y-DOTATATE. Results: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was <10%, <5%, and <10%, respectively. The absorbed-dose values calculated by OLINDA were in agreement with the mean dose values obtained by the S-voxel method (difference, <10%). Conclusions: The results confirm that, with the hybrid SPECT-CT system, quantitative analysis of SPECT 90Y-Bremsstrahlung images and the generation of three-dmensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy. © Mary Ann Liebert, Inc. 2009.
Digital Object Identifier (DOI): 10.1089/cbr.2008.0543
Handle: http://hdl.handle.net/11392/2383047
Appare nelle tipologie:03.1 Articolo su rivista

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