A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.

Antiproliferative Activity of Novel Isatinyl/Indanyl Nitrones (INs) as Potential Spin Trapping of Free Radical Intermediates

Feriotto G;Mischiati C;
2018

Abstract

A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.
Maiuolo, L; Feriotto, G; Algieri, V; Nardi, M; Russo, B; Di Gioia, Ml; Furia, E; Tallarida, Ma; Mischiati, C; De Nino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2382308
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