A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, antioxidant properties of these substrates was measured by DPPH test to report the biological activity with their spin trapping action. In particular, one substrate has showed very high both biological and scavenging activity, probably due to strong correlation between spin trapping activity and structure.
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|Titolo:||Antiproliferative Activity of Novel Isatinyl/Indanyl Nitrones (INs) as Potential Spin Trapping of Free Radical Intermediates|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||03.1 Articolo su rivista|