Mortality and morbidity in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) are still high . A huge amount of the myocardial damage is related to the mitochondrial events happening during reperfusion . Several drugs directly and indirectly targeting mitochondria have been administered at the time of the PCI and their effect on fatal (all-cause mortality, cardiovascular (CV) death) and non fatal (hospital readmission for heart failure (HF)) outcomes have been tested showing conflicting results [3â16]. Data from 15 trials have been pooled with the aim to analyze the effect of drug administration versus placebo on outcome . Subgroup analysis are here analyzed: considering only randomized clinical trial (RCT) on cyclosporine or nicorandil [3â5,9â11], excluding a trial on metoprolol  and comparing trial with follow-up length <12 months versus those with longer follow-up [3â16]. This article describes data related article titled âClinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trialsâ .
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|Titolo:||Data on administration of cyclosporine, nicorandil, metoprolol on reperfusion related outcomes in ST-segment Elevation Myocardial Infarction treated with percutaneous coronary intervention|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||03.1 Articolo su rivista|