The 2014-17 updates of the Global Initiative for Asthma (GINA) introduced major revisions regarding heterogeneous airways disease, targeted treatment, and effective implementation. Two reviews of the 2015 literature on asthma were also recently published. We are witnessing a revolutionary approach to asthma, lung diseases and medicine in general. Systems biology approaches have begun to show how to address the complexity of diseases, in diagnosis, differential diagnosis, assessment of severity, monitoring, and treatment . Several papers have been published since 2015, particularly in the field of severe asthma. They are mostly observational and cross-sectional studies, particularly in type 2 (T2)-high inflammation in mild to severe asthmatics.