The advantage of women in cancer survival: An analysis of EUROCARE-4 data

We analysed 1.6 million population-based EUROCARE-4 cancer cases (26 cancer sites, excluding sex-specific sites, and breast) from 23 countries to investigate the role of sex in cancer survival according to age at diagnosis, site, and European region. For 15 sites (salivary glands, head and neck, oesophagus, stomach, colon and rectum, pancreas, lung, pleura, bone, melanoma of skin, kidney, brain, thyroid, Hodgkin disease and non-Hodgkin's lymphoma) age- and region-adjusted relative survival was significantly higher in women than men. By multivariable analysis, women had significantly lower relative excess risk (RER) of death for the sites listed above plus multiple myeloma. Women significantly had higher RER of death for biliary tract, bladder and leukaemia. For all cancers combined women had a significant 5% lower RER of death. Age at diagnosis was the main determinant of the women's advantage, which, however, decreased with increasing age, becoming negligible in the elderly, suggesting that sex hormone patterns may have a role in women's superior ability to cope with cancer. © 2008 Elsevier Ltd. All rights reserved.

Data di pubblicazione: 2009
Titolo: The advantage of women in cancer survival: An analysis of EUROCARE-4 data
Autori: Micheli, A.; Ciampichini, R.; Oberaigner, W.; Ciccolallo, L.; de Vries, E.; Izarzugaza, I.; Zambon, P.; Gatta, G.; De Angelis, R.; Oberaigner, W.; Hackl, M.; Van Eycken, E.; Verstreken, Martine; Holub, J.; Jurickova, L.; Storm, H. H.; Engholm, G.; Hakulinen, T.; Belot, A.; Hedelin, G.; Velten, M.; Tron, I.; Le Gall, E.; Launoy, G.; Guizard, A. V.; Faivre, J.; Bouvier, A. M.; Carli, P. M.; Maynadie, M.; Danzon, A.; Buemi, A.; Tretarre, B.; Lacour, B.; Desandes, E.; Colonna, M.; Molinie, F.; Bara, S.; Schvartz, C.; Ganry, O.; Grosclaude, P.; Brenner, H.; Kaatsch, P.; Ziegler, H.; Tryggvadottir, L.; Comber, H.; Berrino, F.; Allemani, C.; Baili, P.; Ciampichini, R.; Ciccolallo, L.; Gatta, G.; Micheli, A.; Sant, M.; Sowe, S.; Zigon, G.; Tagliabue, G.; Contiero, P.; Bellu`, F.; Giacomin, A.; Ferretti, S.; Serraino, D.; Dal Maso, L.; De Dottori, M.; D. e. Paoli, A.; Zanier, L.; Vercelli, M.; Orengo, M. A.; Casella, C.; Quaglia, A.; Pannelli, F.; Federico, M.; Rashid, I.; Cirilli, C.; Fusco, M.; Traina, A.; De Lisi, V.; Bozzani, F.; Magnani, C.; Pastore, G.; Tumino, R.; La Rosa, M. G.; Spata, E.; Sigona, A.; Mangone, L.; Falcini, F.; Foca, F.; Giorgetti, S.; Senatore, G.; Iannelli, A.; Budroni, M.; Patriarca, S.; Zanetti, R.; Rosso, S.; Piffer, S.; Franchini, S.; Paci, E.; Crocetti, E.; La Rosa, F.; Stracci, F.; Cassetti, T.; Zambon, P.; Guzzinati, S.; Caldora, M.; Capocaccia, R.; Carrani, E.; De Angelis, R.; Francisci, S.; Grande, E.; Inghelmann, R.; Lenz, H.; Martina, L.; Roazzi, P.; Santaquilani, M.; Simonetti, A.; Tavilla, A.; Verdecchia, A.; Dalmas, M.; Langmark, F.; Bray, F.; Johannesen, T. B.; Rachtan, J.; Gozdz, S.; Siudowska, U.; Mezyk, R.; Bielska-Lasota, M.; Zwierko, M.; Pinheiro, P. S.; Primic-Zakelj, M.; Mateos, A.; Izarzugaza, I.; Torrella-Ramos, A.; Zurriaga, Oscar; Marcos-Gragera, R.; Vilardell, M. L.; A., Izquierdo; Martinez-Garcia, C.; Sanchez, M. J.; Navarro, C.; Chirlaque, M. D.; Peris-Bonet, R.; Ardanaz, E.; Moreno, C.; Galceran, J.; Klint, A.; Talback, M.; Jundt, G.; Usel, M.; Frick, H.; Ess, S. M.; Bordoni, A.; Luthi, J. C.; Konzelmann, I.; Probst, N.; Lutz, J. M.; Pury, P.; Visser, O.; Otter, R.; Schaapveld, M.; Coebergh, J. W. W.; Janssen-Heijnen, M. L.; Louis van der Heijden, Null; Greenberg, D. C.; Coleman, M. P.; Woods, Laura; Moran, T.; Forman, D.; Cooper, N.; Roche, M.; Verne, J.; Mã¸ller, H.; Meechan, D.; Poole, J.; Lawrence, G.; Stiller, C.; Gavin, A.; Black, R. J.; Brewster, D. H.; Steward, J. A.
Rivista: EUROPEAN JOURNAL OF CANCER
Parole Chiave: Cancer survival; EUROCARE; Gender differences; Sex hormones; Adolescent; Adult; Age Distribution; Age of Onset; Aged; Aged, 80 and over; Diagnosis-Related Groups; Europe; Female; Humans; Male; Middle Aged; Neoplasms; Residence Characteristics; Risk Assessment; Sex Distribution; Survival Analysis; Young Adult; Sex Factors; Oncology; Cancer Research
Abstract in inglese: We analysed 1.6 million population-based EUROCARE-4 cancer cases (26 cancer sites, excluding sex-specific sites, and breast) from 23 countries to investigate the role of sex in cancer survival according to age at diagnosis, site, and European region. For 15 sites (salivary glands, head and neck, oesophagus, stomach, colon and rectum, pancreas, lung, pleura, bone, melanoma of skin, kidney, brain, thyroid, Hodgkin disease and non-Hodgkin's lymphoma) age- and region-adjusted relative survival was significantly higher in women than men. By multivariable analysis, women had significantly lower relative excess risk (RER) of death for the sites listed above plus multiple myeloma. Women significantly had higher RER of death for biliary tract, bladder and leukaemia. For all cancers combined women had a significant 5% lower RER of death. Age at diagnosis was the main determinant of the women's advantage, which, however, decreased with increasing age, becoming negligible in the elderly, suggesting that sex hormone patterns may have a role in women's superior ability to cope with cancer. © 2008 Elsevier Ltd. All rights reserved.
Digital Object Identifier (DOI): 10.1016/j.ejca.2008.11.008
Handle: http://hdl.handle.net/11392/2380612
Appare nelle tipologie:03.1 Articolo su rivista

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