Patients with soft tissue sarcoma (STS) experienced better outcomes when treated according to existing clinical practice guidelines either at reference institution or dedicated treatment networks. Despite increasing evidence supporting referral to sarcoma specialised units, up to half of patients are not managed according to guidelines, particularly those in the early stage of their disease requiring surgery. Also, criteria to certify expertise of institutions, such as the treatment volume, are debated and health authorities have only recently started identification of these centres and creation of treatment networks in Europe as well as in several countries. This process have important implications for both patient outcomes and innovation of existing treatment strategies through clinical research, making improvement of clinical pathways a priority for health care authorities. This article will discuss issues with management of patients with STS, such as pathological diagnosis and adherence to guidelines, and the definition of referral centres and networks will be illustrated along with existing experiences and population-based data.

Treatment challenges in and outside a network setting: Soft tissue sarcomas

Stefano, Ferretti;
2019

Abstract

Patients with soft tissue sarcoma (STS) experienced better outcomes when treated according to existing clinical practice guidelines either at reference institution or dedicated treatment networks. Despite increasing evidence supporting referral to sarcoma specialised units, up to half of patients are not managed according to guidelines, particularly those in the early stage of their disease requiring surgery. Also, criteria to certify expertise of institutions, such as the treatment volume, are debated and health authorities have only recently started identification of these centres and creation of treatment networks in Europe as well as in several countries. This process have important implications for both patient outcomes and innovation of existing treatment strategies through clinical research, making improvement of clinical pathways a priority for health care authorities. This article will discuss issues with management of patients with STS, such as pathological diagnosis and adherence to guidelines, and the definition of referral centres and networks will be illustrated along with existing experiences and population-based data.
Sandro, Pasquali; Sylvie, Bonvalot; Dimitri, Tzanis; G., Casali Paolo; Annalisa, Trama; Alessandro, Gronchi; Wg, Rarecarenet; Hackl, Monika; Van Eycken, Elizabeth; Henau, Kris; Dimitrova, Nadya; Sekerija, Mario; Dušek, Ladislav; Mägi, Margit; Malila, Nea; Leinonen, Maarit; Velten, Michel; Troussard, Xavier; Bouvier, Veronique; Guizard, Anne-Valérie; Bouvier, Anne-Marie; Arveux, Patrick; Maynadié, Marc; Woronoff, Anne-Sophie; Robaszkiewicz, Michel; Baldi, Isabelle; Monnereau, Alain; Tretarre, Brigitte; Colonna, Marc; Molinié, Florence; Bara, Simona; Schvartz, Claire; e Lapôtre-Ledoux, Bénédict; Grosclaude, Pascale; Stabenow, Roland; Luttmann, Sabine; Nennecke, Alice; Engel, Jutta; Schubert-Fritschle, Gabriele; Heidrich, Jan; Holleczek, Bernd; Gunnlaugur Jónasson, Jón; Clough-Gorr, Kerri; Comber, Harry; Mazzoleni, Guido; Giacomin, Adriano; Sutera Sardo, Antonella; Barchielli, Alessandro; Serraino, Diego; De Angelis, Roberta; Mallone, Sandra; Tavilla, Andrea; Pierannunzio, Daniela; Rossi, Silvia; Santaquilani, Mariano; Knijn, Arnold; Pannozzo, Fabio; Gennaro, Valerio; Benfatto, Lucia; Ricci, Paolo; Autelitano, Mariangela; Spagnoli, Gianbattista; Fusco, Mario; Usala, Mario; Vitale, Francesco; Michiara, Maria; Tumino, Rosario; Mangone, Lucia; Falcini, Fabio; Ferretti, Stefano; Filiberti, Rosa Angela; Marani, Enza; Iannelli, Arturo; Sensi, Flavio; Piffer, Silvano; Gentilini, Maria; Madeddu, Anselmo; Ziino, Antonio; Maspero, Sergio; Candela, Pina; Stracci, Fabrizio; Tagliabue, Giovanna; Rugge, Massimo; Trama, Annalisa; Gatta, Gemma; Botta, Laura; Capocaccia, Riccardo; Pildava, Santa; Smailyte, Giedre; Calleja, Neville; Børge Johannesen, Tom; Rachtan, Jadwiga; Góźdź, Stanisław; Błaszczyk, Jerzy; Kępska, Kamila; Forjaz de Lacerda, Gonçalo; Bento, Maria José; Miranda, Ana; Safaei Diba, Chakameh; Almar, Enrique; a Larrañaga, Nere; Lopez de Munain, Arantza; Torrella-Ramos, Ana; a Díaz García, José Marí; Marcos-Gragera, Rafael; Sanchez, Maria Josè; Navarro, Carmen; Salmeron, Diego; Moreno-Iribas, Conchi; Galceran, Jaume; Carulla, Marià; Mousavi, Mohsen; Bouchardy, Christine; Ess, Silvia M.; Bordoni, Andrea; Konzelmann, Isabelle; Rashbass, Jem; a Gavin, Ann; Brewster, David H.; Wyn Huws, Dyfed; Visser, Otto; Bielska-Lasota, Magdalena; Primic-Zakelj, Maja; Kunkler, Ian; Benhamou, Ellen
File in questo prodotto:
File Dimensione Formato  
Treatment challenges in and outside a network setting, Soft tissue sarcomas.pdf

solo gestori archivio

Descrizione: in press
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 784.95 kB
Formato Adobe PDF
784.95 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2380543
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 16
social impact