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EnglishNucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies.
| Data di pubblicazione: | 2017 | |
| Titolo: | A Purinergic Trail for Metastases | |
| Autori: | Ferrari, Davide; Malavasi, Fabio; Antonioli, Luca | |
| Rivista: | TRENDS IN PHARMACOLOGICAL SCIENCES | |
| Keywords: | chemotaxis; extracellular nucleotides; P1 receptors; P2 receptors; tumor; Animals; Humans; Neoplasm Metastasis; Neoplasms; Purine Nucleosides; Purine Nucleotides; Receptors, Purinergic P1; Receptors, Purinergic P2; Signal Transduction; Toxicology; Pharmacology | |
| Abstract in inglese: | Nucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies. | |
| Digital Object Identifier (DOI): | 10.1016/j.tips.2016.11.010 | |
| Handle: | http://hdl.handle.net/11392/2380507 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Ferrari et al_Trends in Pharmac Sci 2017.pdf | versione editoriale | Full text (versione editoriale) | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
| Postprint11392-2380507.pdf | post print | Post-print |  | Open Access Visualizza/Apri |
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