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EnglishAlthough some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL).
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| Data di pubblicazione: | 2008 | |
| Titolo: | Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis | |
| Autori: | Nicolin, V; Narducci, P; Celeghini, C | |
| Rivista: | EUROPEAN JOURNAL OF HISTOCHEMISTRY | |
| Keywords: | TRAIL, osteoclastogenesis, OPG | |
| Abstract in inglese: | Although some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL). | |
| Handle: | http://hdl.handle.net/11392/2380312 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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