Rett syndrome (RTT) and autism spectrum disorders (ASDs) are not merely expression of brain dysfunction but also reflect the perturbation of physiological/metabolic homeostasis. Accordingly, both disorders appear to be associated with increased vulnerability to toxicants produced by redox imbalance, inflammation, and pollution, and impairment of systemic-detoxifying agents could play a role in the exacerbation of these detrimental processes. To check this hypothesis, the activities of two mechanistically related blood-based enzymes, paraoxonase-1 (arylesterase, paraoxonase, and lactonase), and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) were measured in the serum of 79 ASD and 95 RTT patients, and 77 controls. Lactonase and Lp-PLA(2) showed a similar trend characterized by significantly lower levels of both activities in ASD compared to controls and RTT (p < 0 001 for all pairwise comparisons). Noteworthy, receiving operator curve (ROC) analysis revealed that lactonase and, mostly, Lp-PLA(2) were able to discriminate between ASD and controls (lactonase: area under curve, AUC = 0.660; Lp-PLA(2), AUC = 0.780), and, considering only females, between ASD and RTT (lactonase, AUC = 0.714; Lp-PLA(2), AUC = 0.881). These results suggest that lactonase and, especially, Lp-PLA(2) activities might represent novel candidate biomarkers for ASD.
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|Titolo:||Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||03.1 Articolo su rivista|