Antidyskinetic effect of A2A and 5HT1A​/1B receptor ligands in two animal models of Parkinson's disease

In 6-hydroxydopamine–lesioned rats, com-bined administ ration ofL-dopa (4 mg/kg) plus eltoprazine(0.6 mg/kg) plus preladenant (0.3 mg/kg) significantly pre-vented or reduced dyskinetic-like behavior without impair-ing motor activity. Zif-268 was increased in the striatum ofrat s tr eated withL-dopa and L-dopa plus pr eladen ant com-pared with vehicle. In co ntrast, ra ts treated with eltoprazine(with or without pr eladenant) had lower zif-268 activationafter ch ronic treatment in both the dyskinetic andL-dopa–non-primed groups.

Data di pubblicazione: 2016
Titolo: Antidyskinetic effect of A2A and 5HT1A​/1B receptor ligands in two animal models of Parkinson's disease
Autori: Pinna, Annalisa; Wai Kin D., Ko; Costa, Giulia; Tronci, Elisabetta; Fidalgo, Camino; Simola, Nicola; Qin, Li; AGHAZADEH TABRIZI, Mojgan; Bezard, Erwan; Carta, Manolo; Morelli, Micaela
Rivista: MOVEMENT DISORDERS
Abstract: In 6-hydroxydopamine–lesioned rats, com-bined administ ration ofL-dopa (4 mg/kg) plus eltoprazine(0.6 mg/kg) plus preladenant (0.3 mg/kg) significantly pre-vented or reduced dyskinetic-like behavior without impair-ing motor activity. Zif-268 was increased in the striatum ofrat s tr eated withL-dopa and L-dopa plus pr eladen ant com-pared with vehicle. In co ntrast, ra ts treated with eltoprazine(with or without pr eladenant) had lower zif-268 activationafter ch ronic treatment in both the dyskinetic andL-dopa–non-primed groups.
Digital Object Identifier (DOI): 10.1002/mds.264 75
Handle: http://hdl.handle.net/11392/2378719
Appare nelle tipologie:03.1 Articolo su rivista

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