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EnglishIn 6-hydroxydopamine–lesioned rats, com-bined administ ration ofL-dopa (4 mg/kg) plus eltoprazine(0.6 mg/kg) plus preladenant (0.3 mg/kg) significantly pre-vented or reduced dyskinetic-like behavior without impair-ing motor activity. Zif-268 was increased in the striatum ofrat s tr eated withL-dopa and L-dopa plus pr eladen ant com-pared with vehicle. In co ntrast, ra ts treated with eltoprazine(with or without pr eladenant) had lower zif-268 activationafter ch ronic treatment in both the dyskinetic andL-dopa–non-primed groups.
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| Titolo: | Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Abstract: | In 6-hydroxydopamine–lesioned rats, com-bined administ ration ofL-dopa (4 mg/kg) plus eltoprazine(0.6 mg/kg) plus preladenant (0.3 mg/kg) significantly pre-vented or reduced dyskinetic-like behavior without impair-ing motor activity. Zif-268 was increased in the striatum ofrat s tr eated withL-dopa and L-dopa plus pr eladen ant com-pared with vehicle. In co ntrast, ra ts treated with eltoprazine(with or without pr eladenant) had lower zif-268 activationafter ch ronic treatment in both the dyskinetic andL-dopa–non-primed groups. |
| Handle: | http://hdl.handle.net/11392/2378719 |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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