Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas. Aims: This study aimed at evaluating the sensitivity of 18F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas. Methods: We retrospectively compared the results of 92 18F-FDG PET/CT studies followed by colonoscopy. Colonoscopy and histology were considered as the gold standard. Results: One hundred fifty-seven lesions were observed. All the 12 malignancies were identified by 18F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected. At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10 mm, presence of villous component and high-grade dysplasia and the ability of 18F-FDG PET/CT to detect adenomas. 18F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered. Conclusion: 18F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy. © 2009 Editrice Gastroenterologica Italiana S.r.l.
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Data di pubblicazione: | 2010 | |
Titolo: | Positron emission tomography for the detection of colorectal adenomas | |
Autori: | Ravizza, Davide; Bartolomei, Mirco; Santoro, Luigi; Tamayo, Darina; Fiori, Giancarla; Trovato, Cristina; De Cicco, Concetta; De Roberto, Giuseppe; Paganelli, Giovanni; Crosta, Cristiano | |
Rivista: | DIGESTIVE AND LIVER DISEASE | |
Parole Chiave: | 18F-fluorodeoxyglucose positron emission tomography; Colonic adenoma; Colonic neoplasm; PET/CT; Hepatology; Gastroenterology | |
Abstract in inglese: | Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas. Aims: This study aimed at evaluating the sensitivity of 18F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas. Methods: We retrospectively compared the results of 92 18F-FDG PET/CT studies followed by colonoscopy. Colonoscopy and histology were considered as the gold standard. Results: One hundred fifty-seven lesions were observed. All the 12 malignancies were identified by 18F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected. At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10 mm, presence of villous component and high-grade dysplasia and the ability of 18F-FDG PET/CT to detect adenomas. 18F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered. Conclusion: 18F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy. © 2009 Editrice Gastroenterologica Italiana S.r.l. | |
Digital Object Identifier (DOI): | 10.1016/j.dld.2009.06.018 | |
Handle: | http://hdl.handle.net/11392/2378440 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |