The background induced by the high penetration power of the Î³ radiation is the main limiting factor of the current radio-guided surgery (RGS). To partially mitigate it, a RGS with Î²+ -emitting radio-tracers has been suggested in literature. Here we propose the use of Î²- -emitting radio-tracers and Î²- probes and discuss the advantage of this method with respect to the previously explored ones: the electron low penetration power allows for simple and versatile probes and could extend RGS to tumours for which background originating from nearby healthy tissue makes Î³ probes less effective. We developed a Î²- probe prototype and studied its performances on phantoms. By means of a detailed simulation we have also extrapolated the results to estimate the performances in a realistic case of meningioma, pathology which is going to be our first in-vivo test case. A good sensitivity to residuals down to 0.1 ml can be reached within 1 s with an administered activity smaller than those for PET-scans thus making the radiation exposure to medical personnel negligible.
|Titolo:||A novel radioguided surgery technique exploiting Î²- decays|
|Data di pubblicazione:||2014|
|Appare nelle tipologie:||03.1 Articolo su rivista|