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EnglishThe background induced by the high penetration power of the γ radiation is the main limiting factor of the current radio-guided surgery (RGS). To partially mitigate it, a RGS with β+ -emitting radio-tracers has been suggested in literature. Here we propose the use of β- -emitting radio-tracers and β- probes and discuss the advantage of this method with respect to the previously explored ones: the electron low penetration power allows for simple and versatile probes and could extend RGS to tumours for which background originating from nearby healthy tissue makes γ probes less effective. We developed a β- probe prototype and studied its performances on phantoms. By means of a detailed simulation we have also extrapolated the results to estimate the performances in a realistic case of meningioma, pathology which is going to be our first in-vivo test case. A good sensitivity to residuals down to 0.1 ml can be reached within 1 s with an administered activity smaller than those for PET-scans thus making the radiation exposure to medical personnel negligible.
| Data di pubblicazione: | 2014 | |
| Titolo: | A novel radioguided surgery technique exploiting β- decays | |
| Autori: | Camillocci, E. Solfaroli; Baroni, G.; Bellini, F.; Bocci, V.; Collamati, F.; Cremonesi, M.; De Lucia, E.; Ferroli, P.; Fiore, S.; Grana, C. M.; Marafini, M.; Mattei, I.; Morganti, S.; Paganelli, G.; Patera, V.; Piersanti, L.; Recchia, L.; Russomando, A.; Schiariti, M.; Sarti, A.; Sciubba, A.; Voena, C.; Faccini, R. | |
| Rivista: | SCIENTIFIC REPORTS | |
| Parole Chiave: | Multidisciplinary; Medicine (all) | |
| Abstract in inglese: | The background induced by the high penetration power of the γ radiation is the main limiting factor of the current radio-guided surgery (RGS). To partially mitigate it, a RGS with β+ -emitting radio-tracers has been suggested in literature. Here we propose the use of β- -emitting radio-tracers and β- probes and discuss the advantage of this method with respect to the previously explored ones: the electron low penetration power allows for simple and versatile probes and could extend RGS to tumours for which background originating from nearby healthy tissue makes γ probes less effective. We developed a β- probe prototype and studied its performances on phantoms. By means of a detailed simulation we have also extrapolated the results to estimate the performances in a realistic case of meningioma, pathology which is going to be our first in-vivo test case. A good sensitivity to residuals down to 0.1 ml can be reached within 1 s with an administered activity smaller than those for PET-scans thus making the radiation exposure to medical personnel negligible. | |
| Digital Object Identifier (DOI): | 10.1038/srep04401 | |
| Handle: | http://hdl.handle.net/11392/2378232 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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