In hospital, air conditioning and air treatment systems are of great importance both for functional and energetic point of view. In fact, these systems must guarantee the conditions of hygrothermal air quality and comfort for people (patients, staff, visitors), but also meet the operational requirements related to the medical activities in specific environments or departments. In particular, diagnosis and surgical activities request to ensure a high air quality conditions in order to ensure the appropriate environments of asepsis and hygiene [1-3]. The aim of this study is to evaluate the possible energy saving solutions to optimize and reduce energy demand [4-5] in the health facilities. Particular attention is focused to the operating theaters, which, because of the type of technological systems used, have a major impact on energy demand the entire healthcare facility.